HER2 Support Group Forums - View Single Post - Insulin potentiation thereapy: makes sense considering metformin benefits

Rich66 · 11-29-2009, 11:22 AM

No doubt it's controversial. but the way it seems to be practiced is not quite the way ACS describes it. Warburg effect and glycolysis has been around and ignored for a long time. There are numerous indications (Metformin) the concept has some merit. Whether IPT has merit is hard to tell considering the lack of formal trials. But at an admittedly simplistic level, it seems to exploit the same mechanisms that Glucose based PET imaging does. They've known for many years to keep diabetics from taking their Metformin because it interferes with tumor activity. Well...common sense would tell you that's a good thing. Now, many years later, science seems to be saying "Maybe metformin is good." IPT looks like an attempt to harness the same mechanism in a more aggressive fashion. Just saying Metformin was basically sitting under their nose for years. Maybe IPT is the same. and taking it a little further, maybe the supposed myth of "sugar feeds cancer" is at the core. The connections between cancer, metabolism and diabetes continue to be discovered.
http://www.reuters.com/article/healt...5AO4VO20091125
http://www.ncbi.nlm.nih.gov/pubmed/14713323
Metabolic syndrome

Many researchers are piling on to the idea that PET scan uptake a short time after treatment can show whether a given chemo is reaching and affecting (slowing down) the tumor cells. Again, common sense. It would be interesting to see how IPT treated tumor cells look a few days after treatment. Although not primed with extensive sugar deprivation via insulin, it would be very interesting to look at cancer patients' records who had chemo immediately after glucose injection/PET scan.

Started an IPT thread in Articles of interest:
http://her2support.org/vbulletin/showthread.php?t=42119

11-29-2009, 11:22 AM	#3
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Insulin potentiation thereapy: makes sense considering metformin benefits No doubt it's controversial. but the way it seems to be practiced is not quite the way ACS describes it. Warburg effect and glycolysis has been around and ignored for a long time. There are numerous indications (Metformin) the concept has some merit. Whether IPT has merit is hard to tell considering the lack of formal trials. But at an admittedly simplistic level, it seems to exploit the same mechanisms that Glucose based PET imaging does. They've known for many years to keep diabetics from taking their Metformin because it interferes with tumor activity. Well...common sense would tell you that's a good thing. Now, many years later, science seems to be saying "Maybe metformin is good." IPT looks like an attempt to harness the same mechanism in a more aggressive fashion. Just saying Metformin was basically sitting under their nose for years. Maybe IPT is the same. and taking it a little further, maybe the supposed myth of "sugar feeds cancer" is at the core. The connections between cancer, metabolism and diabetes continue to be discovered. http://www.reuters.com/article/healt...5AO4VO20091125 http://www.ncbi.nlm.nih.gov/pubmed/14713323 Metabolic syndrome Many researchers are piling on to the idea that PET scan uptake a short time after treatment can show whether a given chemo is reaching and affecting (slowing down) the tumor cells. Again, common sense. It would be interesting to see how IPT treated tumor cells look a few days after treatment. Although not primed with extensive sugar deprivation via insulin, it would be very interesting to look at cancer patients' records who had chemo immediately after glucose injection/PET scan. Started an IPT thread in Articles of interest: http://her2support.org/vbulletin/showthread.php?t=42119 __________________ Mom's treatment history (link)