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Rich66 · 11-22-2009, 05:53 PM

Crit Rev Immunol. 2008;28(2):95-107.
Pathogen-associated molecular pattern in cancer immunotherapy.

Hobohm U, Stanford JL, Grange JM.
University of Applied Sciences, Bioinformatics, Wiesenstrasse 14, D-35390 Giessen, Germany. uwe.hobohm@tg.fh-giessen.de
Observations from different research frontiers--epidemiological data, case studies on spontaneous regressions from cancer, clinical studies, tumor immunology--indicate that exposure by vaccination or infection to pathogen-associated molecular patterns (PAMP) can have beneficial effects on neoplastic diseases, both prophylactically and therapeutically. These effects have not yet been harnessed to their full extent for the prophylaxis and therapy of cancer. Here, we summarize clinical, epidemiological, and experimental data and discuss the role of PAMP in cancer therapy.

PMID: 18540826 [PubMed - indexed for MEDLINE]

11-22-2009, 05:53 PM	#2
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Fever therapy Crit Rev Immunol. 2008;28(2):95-107. Pathogen-associated molecular pattern in cancer immunotherapy. Hobohm U, Stanford JL, Grange JM. University of Applied Sciences, Bioinformatics, Wiesenstrasse 14, D-35390 Giessen, Germany. uwe.hobohm@tg.fh-giessen.de Observations from different research frontiers--epidemiological data, case studies on spontaneous regressions from cancer, clinical studies, tumor immunology--indicate that exposure by vaccination or infection to pathogen-associated molecular patterns (PAMP) can have beneficial effects on neoplastic diseases, both prophylactically and therapeutically. These effects have not yet been harnessed to their full extent for the prophylaxis and therapy of cancer. Here, we summarize clinical, epidemiological, and experimental data and discuss the role of PAMP in cancer therapy. PMID: 18540826 [PubMed - indexed for MEDLINE]