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Re: How can you tell if it's necrosis or cancer?
Flori - I think since your tumor markers have returned to normal that is good support for necrosis not activity. If an MRI can distinuish that I'd ask to have that done. As far as the t-dm1 trial some trials require 'measurable disease' of which bone mets don't qualify, but there are some more trials now that will take 'non measurable' if you fit the other criteria. I have bone mets and have been searching for a long time for a trial that will fit me with no luck. Nothing in my area of Minneapolis, some in surrounding states, but so far no luck making connections.
If more investigation shows no increased activity I agree with your doc to stay on the current trt at least for now - it's working. Save the t-dm1 for down the road if needed.
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Pam
6/01 IBC er+ her2+stage IIIb; mastecomy
7/01 AC, taxol; radiation
2/02 tamoxifen
9/02 stage IV bone mets femara
1/03 taxotere/herceptin/aredia
6/03 herceptin, aredia & faslodex
1/04 navelbine, herceptin, aredia
2/05 herceptin/aredia
7/05 xeloda/herceptin/aredia
3/07 xeloda/tykerb/aredia
5/08 taxol/avastin/aredia
2/09 gemzar/herceptin/zometa
7/09 Taxol/Carbo/Herceptin, zometa
10/09 navelbine/herceptin & zometa
2/10 herceptin & tykerb & zometa
4/10 add xeloda &aromasin
10/10 dx with dermatomyiositis triggered by cancer
11/10 restart herceptin, tykerb, zometa
12/10 surgery-place rod in R femur to stabilize bone
1/11 radiation to R femur - 20 tx
2/11 2nd surgery - rod in Left femur
2/11 tx eribulen -- suspended dx brain mets
3/11 brain mets wbr 20 tx
4/11 halaven; discontine 8/11 not working
8/11 radiation to left femur 20 tx'
8-9/11 rad to lower spine
9/11 abraxane/herceptin/zometa
9/12 xeloda/herceptin/zometa
12/12 ablation of liver
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