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why then did the HERA study and the North American adjuvant herceptin trials get such similar results ie giving herceptin alone AFTER chemotherapy (actually quite a long time after) vs giving herceptin and chemo simultaneously
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I think the answer is that science has yet to totally understand all the means by which Herceptin works. It has always struck me as funny that they developed this fantastic drug that shows great results, but are still in the dark as to
how it works - for example, I have in my files a study of neoadjuvant Herceptin treatment, designed to "elucidate the means" by which it works. Rich66 has posted a review of the mechanisms of action of Herceptin in the articles forum that lists at least 5 different ones. Like alot of things (asprin, for one) I am sure this drug has many more uses that are currently undiscovered.
Hopeful