HER2 Support Group Forums - View Single Post - herceptin seems to prevent repair of DNA damage caused by chemotherapeutic agents

Lani · 11-07-2009, 09:24 AM

It was only the her2 located in the NUCLEUS which affected the ability to repair DNA damage caused by chemotherapy agents. Her2 normally sits across the membrane between the cell and its exterior, not in the nucleus.
Cytoplasmic/membrane her2 DID NOT in this paper did not affect any DNA repair ability.

How her2 can translocate or otherwise be found in the nucelus
is still being worked out--but the interesting thing is, that the herceptin trials' results in North America did not differ TERRIBLY markedly from those throughout the rest of the world even though herceptin was given concurrently in the former and not in the latter.

The scientists are going to have to look into this much more fully before an explanation emerges, but it may cause them to alter the way they do trials to try to work this out.

11-07-2009, 09:24 AM	#5
Lani Senior Member Join Date: Mar 2006 Posts: 4,780	Re: herceptin seems to prevent repair of DNA damage caused by chemotherapeutic agent It was only the her2 located in the NUCLEUS which affected the ability to repair DNA damage caused by chemotherapy agents. Her2 normally sits across the membrane between the cell and its exterior, not in the nucleus. Cytoplasmic/membrane her2 DID NOT in this paper did not affect any DNA repair ability. How her2 can translocate or otherwise be found in the nucelus is still being worked out--but the interesting thing is, that the herceptin trials' results in North America did not differ TERRIBLY markedly from those throughout the rest of the world even though herceptin was given concurrently in the former and not in the latter. The scientists are going to have to look into this much more fully before an explanation emerges, but it may cause them to alter the way they do trials to try to work this out.