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Becky · 11-05-2009, 06:57 PM

Dianne

I was 50%ER+ and PR negative. There are studies on metastatic women where only Herceptin and an AI were used first line where there was great response and disease free progression for over 2 years. Therefore, it did prove the combo works. Although not done in early stage, the premise should still hold.

You should discuss with your onc the trials of ER+ but PR neg as Tamoxifen does not do a good job. This is why when I regained my premenopausal status I had my ovaries removed to use Arimidex (even though the jury is still out on that now too). However, I am happy that I was on the AI/Herceptin combo for a full year and I am sure if any cancer cells remained after chemo, that combo got them.

You need to do research or come to peace with yourself with your doctor's guidance on whether you should do hormonal treatment or not.

11-05-2009, 06:57 PM	#4
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Tamoxifen and weakly ER positive women? Dianne I was 50%ER+ and PR negative. There are studies on metastatic women where only Herceptin and an AI were used first line where there was great response and disease free progression for over 2 years. Therefore, it did prove the combo works. Although not done in early stage, the premise should still hold. You should discuss with your onc the trials of ER+ but PR neg as Tamoxifen does not do a good job. This is why when I regained my premenopausal status I had my ovaries removed to use Arimidex (even though the jury is still out on that now too). However, I am happy that I was on the AI/Herceptin combo for a full year and I am sure if any cancer cells remained after chemo, that combo got them. You need to do research or come to peace with yourself with your doctor's guidance on whether you should do hormonal treatment or not. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"