HER2 Support Group Forums - View Single Post - Er- can turn pos after Herceptin

Rich66 · 11-04-2009, 01:49 PM

Just a reminder to those considered ER- before Herceptin. It may have changed your status and given you more options:

Italian investigators gave trastuzumab to 10 patients with HER2-positive, ER-negative breast cancer. Three of the 10 subsequently had upregulation of ER±, and two of the three were treated with letrozole monotherapy and remained progression free for as long as three years
More:
http://her2support.org/vbulletin/showthread.php?t=38998
And recurrence/mets alone can change it too.

And..Tamoxifen can work on both ER+ and - as well as synergize with chemos. Tamoxifen might be useful if no way to check status.

11-04-2009, 01:49 PM	#1
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Reminder: Er- can turn pos after Herceptin Just a reminder to those considered ER- before Herceptin. It may have changed your status and given you more options: Italian investigators gave trastuzumab to 10 patients with HER2-positive, ER-negative breast cancer. Three of the 10 subsequently had upregulation of ER±, and two of the three were treated with letrozole monotherapy and remained progression free for as long as three years More: http://her2support.org/vbulletin/showthread.php?t=38998 And recurrence/mets alone can change it too. And..Tamoxifen can work on both ER+ and - as well as synergize with chemos. Tamoxifen might be useful if no way to check status. __________________ Mom's treatment history (link)