HER2 Support Group Forums - View Single Post - possible gentle long-term strategy for treatment of Stage IV

Rich66 · 11-01-2009, 01:56 PM

Basically, the idea seems to be reduction in toxicity/side effects along with an angiogenic benefit..meaning lower doses more frequently may prevent cancer cells from rebuilding between doses. I get the sense that the approach has been looked at more in the context of traditional (broad) chemos. T-DM1 is such a different animal (highly targeted), I don't know if anyone's considering it applicable. Who knows..maybe that's next.

Here's a definition and brief discussion:
http://www.cancer.gov/ncicancerbulle...n_062706/page4

Here's a paper on 5 years experience at the Sunnybrooke facility mentioned in the abstract Lani posted:
http://content.karger.com/ProdukteDB...=000111479.pdf

11-01-2009, 01:56 PM	#4
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: possible gentle long-term strategy for treatment of Stage IV Basically, the idea seems to be reduction in toxicity/side effects along with an angiogenic benefit..meaning lower doses more frequently may prevent cancer cells from rebuilding between doses. I get the sense that the approach has been looked at more in the context of traditional (broad) chemos. T-DM1 is such a different animal (highly targeted), I don't know if anyone's considering it applicable. Who knows..maybe that's next. Here's a definition and brief discussion: http://www.cancer.gov/ncicancerbulle...n_062706/page4 Here's a paper on 5 years experience at the Sunnybrooke facility mentioned in the abstract Lani posted: http://content.karger.com/ProdukteDB...=000111479.pdf __________________ Mom's treatment history (link)