HER2 Support Group Forums - View Single Post - Interesting Review of Tamoxifen vs. AI study results

Rich66 · 11-01-2009, 01:44 PM

Interesting..and a little disturbing, given the fact that mom had only Arimidex. Mom's current onc is a fan of tamoxifen. He uses it in an in-house protocol that is also applied to ER neg breast cancer as well as other cancers. Kind of a rotation of Taxanes with Tamoxifen synergizing at an ER independent level.
I remember when I was first learning of SERMs and AIs. I asked about combining the two since they work in different ways and was told "that isn't done".
I wonder if this article is pointing to the idea that Tamoxifen up front diminishes the receptor/receiver so that AIs, working at the source/supply, have a better chance.
Eventually I bet they will find Fulvestrant to be better than Tamoxifen in adjuvant since it permanently obliterates the receptor.

11-01-2009, 01:44 PM	#2
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Interesting Review of Tamoxifen vs. AI study results Interesting..and a little disturbing, given the fact that mom had only Arimidex. Mom's current onc is a fan of tamoxifen. He uses it in an in-house protocol that is also applied to ER neg breast cancer as well as other cancers. Kind of a rotation of Taxanes with Tamoxifen synergizing at an ER independent level. I remember when I was first learning of SERMs and AIs. I asked about combining the two since they work in different ways and was told "that isn't done". I wonder if this article is pointing to the idea that Tamoxifen up front diminishes the receptor/receiver so that AIs, working at the source/supply, have a better chance. Eventually I bet they will find Fulvestrant to be better than Tamoxifen in adjuvant since it permanently obliterates the receptor. __________________ Mom's treatment history (link)