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Old 10-26-2009, 08:14 AM   #5
fullofbeans
Senior Member
 
Join Date: Jan 2007
Location: UK
Posts: 617
Re: Cancer spreading either th' blood or lymph..but the difference?

You say "When the immune system gets compensated, the expression of
her2 gene makes more copies, this is the cancer."


Where did you read that (REFERENCE)?

I am a scientist and I am quite aware of what Her-2 overexpression is. However I have never heard that Her-2 overexpression was linked to a defficiency in the immune system which is what you are implying.

What I am asking is references to this statement, as a scientist I can only rely on referenced statement (this site is pretty good at this).

I would be very interested to know if this is backed up by scientific research or simply your thoughts on it. Many thanks.



PS: the Seattle vaccine targets cells with massive overexpression of Her2 (But all cells have Her2, especially in the heart hence muga scan check). I would not think that the vaccine works at all like the HPV vaccine, since the basis is to prevent HPV, since HPV was proven to cause the cancer.
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies

Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..

superior vena cava blocked: stent but face remains puffy

April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.

Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.



'Under no circumstances should you lose hope..' Dalai Lama
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