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Re: taxol/carbo/herceptin not working
Pam, remember the online searches may not bring up all the study locations, especially if there is a "lot" of activity with trials opening/closing as with T-DM1. You might try a different tack, find a study that looks interesting and contact the principle coordinator at Genentech to see if there are new ones coming to a location near you.
I agree, the HSP 90 area is starting to generate some excitement although I am myself not familiar with what the targeting agents are yet. But if you can find a trial of this, it could be worthwhile. Works differently than anything else...
Re Navelbine, I have not had any experience with it - but I do know that people have had really good results with it. Some were in combo with a taxane, some just with Herceptin - and true, these folks were a bit more chemo-naive at the time. But if a therapy is not as heavy in terms of side effects, it doesn't necessarily follow that it is wimpy. It depends on the biology of the cancer.
Keep pushin' girl.
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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