HER2 Support Group Forums - View Single Post - neoadjuvant study shows AI treatment may upregulate her2

Lani · 10-08-2009, 09:19 PM

since there seems to be cross talk between the ER and the her 2 receptor using a drug which irreversibly degrades the ER might possibly be more effective than just starving the ER of its ligand (estrogen)

Having no ER to cross talk with the her2 receptor may be more effective at stopping growth than having a "starved" ER talk to the her2 receptor, upregulate its pathway and give the tumor an alternative pathway to escape the ligand starvation of the ER.

10-08-2009, 09:19 PM	#11
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Re: neoadjuvant study shows AI treatment may upregulate her2 since there seems to be cross talk between the ER and the her 2 receptor using a drug which irreversibly degrades the ER might possibly be more effective than just starving the ER of its ligand (estrogen) Having no ER to cross talk with the her2 receptor may be more effective at stopping growth than having a "starved" ER talk to the her2 receptor, upregulate its pathway and give the tumor an alternative pathway to escape the ligand starvation of the ER.