HER2 Support Group Forums - View Single Post - Tamoxifen and CYP2D6 metabolizer

Aw shucks. I was hoping to get some response. Hasn't anyone been tested before they went on Tamoxifen to see if they are weak, strong or? metabolizers? I just need to know if you were tested - and the test is called the CYP2D6, was it done by bloodtest or cheek swab?
Thanks,
Dianne

__________________
Three years and 5 months NED
Dx: Aug 2008 right breast IDC with 50% of tumor DCIS, Stage II or IIA, tumor size: 2.1 cm
Grade 3
8/9 Richardson/Bloom test
ER+ weakly positive
Alred Score: 4 (suggesting I would strongly benefit from hormone therapy)
PR-,
HER2 positive +++
No vascular invasion
No lymph nodes involved
Surgery: Sept. 9, 2008 -Modified radical mastectomy, right breast. I chose to have a simple mastectomy on the left. Began Taxotere/Carboplatin/Herceptin November, 2008. Finished T/C March 2009. Finished #16 Herceptin Sept. 09. AI's and Tamoxifen made me sick. Began natural Tamoxifen which is Quercetin, I3C and a combo of other supplements. I am also a DES Daughter. There is now a link between DES exposure in utero and breast cancer!

10-03-2009, 12:18 PM	#2
DianneS Senior Member Join Date: Aug 2008 Posts: 327	Re: Tamoxifen and CYP2D6 metabolizer Aw shucks. I was hoping to get some response. Hasn't anyone been tested before they went on Tamoxifen to see if they are weak, strong or? metabolizers? I just need to know if you were tested - and the test is called the CYP2D6, was it done by bloodtest or cheek swab? Thanks, Dianne __________________ Three years and 5 months NED Dx: Aug 2008 right breast IDC with 50% of tumor DCIS, Stage II or IIA, tumor size: 2.1 cm Grade 3 8/9 Richardson/Bloom test ER+ weakly positive Alred Score: 4 (suggesting I would strongly benefit from hormone therapy) PR-, HER2 positive +++ No vascular invasion No lymph nodes involved Surgery: Sept. 9, 2008 -Modified radical mastectomy, right breast. I chose to have a simple mastectomy on the left. Began Taxotere/Carboplatin/Herceptin November, 2008. Finished T/C March 2009. Finished #16 Herceptin Sept. 09. AI's and Tamoxifen made me sick. Began natural Tamoxifen which is Quercetin, I3C and a combo of other supplements. I am also a DES Daughter. There is now a link between DES exposure in utero and breast cancer!