larotaxel
A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.
Larotaxel penetrates the blood brain barrier. Check for
active clinical trials or
closed clinical trials using this agent. (
NCI Thesaurus)
| Code names: | | RPR 109881
RPR 109881A
XRP9881 |