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freyja · 09-24-2009, 08:14 AM

http://www.cancercompass.com/cancer-...m?c=1004:5:1:2

Overexpressed Protein Converts Noninvasive Breast Cancer Into Invasive Disease

NewsRx.com

[The researchers show that 14-3-3(zeta) teams with the oncoprotein ErbB2, also known as HER2, in a two-hit process to convert normal mammary cells to invasive cancer cells.
In addition to identifying this key step in EMT, Yu notes the findings also provide:

A biomarker in 14-3-3(zeta) to identify high-risk patients for more aggressive treatment before their noninvasive breast cancer converts to invasive disease.

New therapeutic targets among the components of the molecular pathway launched by 14-3-3(zeta). Some drugs already aim at these targets, Yu said.

A solution to a puzzling mystery about how a subset of non-invasive breast cancer with excessive presence of a ErbB2/HER2 develops into invasive breast cancer.]

(more at the link above)

09-24-2009, 08:14 AM	#1
freyja Senior Member Join Date: Sep 2008 Location: Eugene, Oregon Posts: 347	article on HER2/14-3-3 combo http://www.cancercompass.com/cancer-...m?c=1004:5:1:2 Overexpressed Protein Converts Noninvasive Breast Cancer Into Invasive Disease NewsRx.com [The researchers show that 14-3-3(zeta) teams with the oncoprotein ErbB2, also known as HER2, in a two-hit process to convert normal mammary cells to invasive cancer cells. In addition to identifying this key step in EMT, Yu notes the findings also provide: A biomarker in 14-3-3(zeta) to identify high-risk patients for more aggressive treatment before their noninvasive breast cancer converts to invasive disease. New therapeutic targets among the components of the molecular pathway launched by 14-3-3(zeta). Some drugs already aim at these targets, Yu said. A solution to a puzzling mystery about how a subset of non-invasive breast cancer with excessive presence of a ErbB2/HER2 develops into invasive breast cancer.] (more at the link above) __________________ "Dancers Against Cancer" in the Eugene, OR Komen Race for the Cure 2010 Diagnosed 8/7/08 with stage 3 invasive ductal carcinoma, micropapillary pattern, Her2 3+, ER+,PR-, grade II, positive lymph nodes. Received 6doses of Taxotere, Carboplatin with Herceptin continuing for a year...DONE. 1/28/09 Left Modified Radical Mastectomy, Right Simple Mastectomy. Surgery pathology: No invasive carcinoma present and 17 lymph nodes removed all negative! Only small amount of carcinoma in situ in left breast. March/April '09, Radiation to left chest wall. Currently involved in Neratinib clinical trial. "Well being I won and wisdom too, I grew and joyed in my growth; from a word to a word I was led to a word from a deed to another deed." (Odin)