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Rich66 · 09-13-2009, 12:57 PM

"Dr. Slamon has stated at several conferences that he believes the best antihormonal treatment for those who are her2+ and treated with herceptin is faslodex, as it works in another way (it causes the estrogen receptors to fall off every cell irreversibly). Now that may be scary in those cells in one's body with estrogen receptors which do not often multiply and thus are unlikely to be replaced with new cells with estrogen receptors. These include the brain. Originally it was thought that faslodex may not cross the blood brain barrier, but a recent article supported that it does."

This is interesting. Based on the way it works, I've often wondered why Faslodex/Fulvestrant wasn't the go to endocrine treatment. There is info suggesting it has synergy with chemo other than Herceptin as well. Is there a quote from Slamon on this? Any info on the negative side effects suggested?

09-13-2009, 12:57 PM	#9
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: herceptin and AI synergy? Lani? anyone? "Dr. Slamon has stated at several conferences that he believes the best antihormonal treatment for those who are her2+ and treated with herceptin is faslodex, as it works in another way (it causes the estrogen receptors to fall off every cell irreversibly). Now that may be scary in those cells in one's body with estrogen receptors which do not often multiply and thus are unlikely to be replaced with new cells with estrogen receptors. These include the brain. Originally it was thought that faslodex may not cross the blood brain barrier, but a recent article supported that it does." This is interesting. Based on the way it works, I've often wondered why Faslodex/Fulvestrant wasn't the go to endocrine treatment. There is info suggesting it has synergy with chemo other than Herceptin as well. Is there a quote from Slamon on this? Any info on the negative side effects suggested?