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Becky · 09-12-2009, 01:26 PM

Evista and Tamoxifen work in the same way - binding to the ER site while AIs prevent the production of estrogen.

That said, Tamoxifen in Her2+ women is said to promote increased activation of Her2 but not if taken together with Herceptin.

One thought to explore with your medical team is going off the AI but switching to Tamoxifen or Evista during the time you are also on Herceptin therapy. You are blocking both receptors but Evista or Tamoxifen are much kinder to the bones (and can actually make the bones better).

Sassy's idea on adding Zometa is also a good one since not only does it rebuild bone but it also is a chemopreventitive (prevents mets not only in the bones but also in soft tissue).

09-12-2009, 01:26 PM	#6
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: herceptin and AI synergy? Lani? anyone? Evista and Tamoxifen work in the same way - binding to the ER site while AIs prevent the production of estrogen. That said, Tamoxifen in Her2+ women is said to promote increased activation of Her2 but not if taken together with Herceptin. One thought to explore with your medical team is going off the AI but switching to Tamoxifen or Evista during the time you are also on Herceptin therapy. You are blocking both receptors but Evista or Tamoxifen are much kinder to the bones (and can actually make the bones better). Sassy's idea on adding Zometa is also a good one since not only does it rebuild bone but it also is a chemopreventitive (prevents mets not only in the bones but also in soft tissue). __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"