I'd like to draw attention to this new paper
Fish oil enhances the antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 on liver cancer cells. partly to dismiss any idea that because I tend to go on about vitamin D3 that I must therefore think this is the answer to everything.
In a way it's true deficiency of Vitamin d does underlie many chronic conditions but so does an imbalance in the ratio of omega 3<>omega 6 and also a deficiency in magnesium will disrupt the proper functioning of over 300different enzymes.
So there are just 3 fundamental anti-inflammatory agents which many readers here will probably have a low or deficient status, and it's no good anyone saying I take the "official" RDA of all three and therefore cannot be deficient. I'm afraid just the "official" RDA for vitamin D is so low it inevitably leads to deficiency status.
I'm sure everyone here is aware that the main dietary source of vitamin d is oily fish and also that oily fish is the main dietary source of omega 3 and this research, albeit on liver cancer, shows that when omega 3 intake is higher the anti proliverative effect of calcitriol 1.25 (the active hormone derived from vitamin d3) is much more pronounced and lower amounts can be used with lower risk of adverse events.
It isn't a case of do I use omega 3 or vitamin d or magnesium?
We know these substances work synergistally>
So rather than put all your eggs in one basket it makes sense to attack on all fronts where possible.