HER2 Support Group Forums - View Single Post - A must watch - Risk Breast cancer and vitamin D 50-80% risk reduction

Ted_Hutchinson · 08-10-2009, 02:57 PM

To understand how much vitamin d someone needs to take you first have to know if they have a cancer diagnosis or are simply trying to reduce the risk of getting cancer. It is one thing to reduce risk is requires more to fight it successfully.

In the paper I discuss here
Effect of vitamin D supplementation on serum 25-hydroxy vitamin
D levels, joint pain, and fatigue in women starting adjuvant
letrozole treatment for breast cancer
They used 50,000 IU per week for 12 weeks and achieved a level between 60~70ng/mL. Which is in the region suggest byDr Cannell of the Vitamin D Council That's approximately 7000iu/daily/D3

For preventing BC a slightly lower level may be fine.
The chart here Showing Chronic Disease incidence prevention by 25(OH)D Level indicates the maximum risk reduction for cancer occurs around the 50~55ng level. and that equates with a daily D3 intake around 5000~6000iu/d.

As far as safety goes Vitamin D adverse events have only been recorded at intakes considerably above those levels. 40,000iu/daily would be needed to push 25(OH)D above `150ng/mL 375 nmol/l It would take some months to achieve that. In trials for MS using megadose amounts even these levels were exceeded without adverse events being recorded however as far as readers here are concerned. Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000 IU/d of vitamin D(3) poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D.

Ideally people will get their 25(OH)D tested so they will know how well they are responding to effective strength supplements. As the first trial I linked to shows it generally takes around 12 weeks to attain and reasonable vitamin d level when taking 50.000iu/week or 7000iu/daily.
This trial provides the cheapest 25(OH)d postal testing for vitamin d that I am aware of.

If anyone knows a cheaper source then do let me know.

It's part of a trial trying to be more precise about what actually is optimum vitamin d status as far as disease prevention is concerned. But the survey they are doing is very simple to complete and as you save about half the cost of the test it's time well spent.

08-10-2009, 02:57 PM	#5
Ted_Hutchinson Member Join Date: Aug 2009 Posts: 15	Re: A must watch - Risk Breast cancer and vitamin D 50-80% risk reduction To understand how much vitamin d someone needs to take you first have to know if they have a cancer diagnosis or are simply trying to reduce the risk of getting cancer. It is one thing to reduce risk is requires more to fight it successfully. In the paper I discuss here Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer They used 50,000 IU per week for 12 weeks and achieved a level between 60~70ng/mL. Which is in the region suggest byDr Cannell of the Vitamin D Council That's approximately 7000iu/daily/D3 For preventing BC a slightly lower level may be fine. The chart here Showing Chronic Disease incidence prevention by 25(OH)D Level indicates the maximum risk reduction for cancer occurs around the 50~55ng level. and that equates with a daily D3 intake around 5000~6000iu/d. As far as safety goes Vitamin D adverse events have only been recorded at intakes considerably above those levels. 40,000iu/daily would be needed to push 25(OH)D above `150ng/mL 375 nmol/l It would take some months to achieve that. In trials for MS using megadose amounts even these levels were exceeded without adverse events being recorded however as far as readers here are concerned. Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000 IU/d of vitamin D(3) poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D. Ideally people will get their 25(OH)D tested so they will know how well they are responding to effective strength supplements. As the first trial I linked to shows it generally takes around 12 weeks to attain and reasonable vitamin d level when taking 50.000iu/week or 7000iu/daily. This trial provides the cheapest 25(OH)d postal testing for vitamin d that I am aware of. If anyone knows a cheaper source then do let me know. It's part of a trial trying to be more precise about what actually is optimum vitamin d status as far as disease prevention is concerned. But the survey they are doing is very simple to complete and as you save about half the cost of the test it's time well spent.