[Lani]

Jean those were bone marrow biopsies/aspirates. They usually take an area of bone from the pelvis (which is supposed to be macroscopically normal but may have microscopic dormant tumor cells)

Here we are talking about a mastoid bone biopsies from an area where they See a macroscopic abnormality

Klaus Pantel has written a lot about the prognosis of those who had tumor cells in their bone marrow at the time of their original surgery and after their chemotherapy. They have a worse prognosis, especially if the tumor cells found in their bone marrow were her2+.