HER2 Support Group Forums - View Single Post - BC-associated metastasis is significantly increased in model of autoimmune arthritis

Hopeful · 07-31-2009, 06:55 AM

Abstract:http://breast-cancer-research.com/co...4/R56/abstract

Article (be patient, it takes a while to download because of the pictures):http://breast-cancer-research.com/co...df/bcr2345.pdf

Please note this study was done in mice, not people. However, the conclusions are provocative:

"Inflammation is a critical hallmark of arthritis and tumor progression. Many processes that occur during arthritis also occur during tumorigenesis. There is increased vascularity in both; and there are common cytokines and growth factors that are regulated in both. The microenvironment in the tumor and arthritis is largely orchestrated by inflammatory cells and growth factors. Thus, it is not unlikely that the two diseases commonly co-exist in women. . . . Our data provide clear evidence for the first time that breast cancer associated secondary metatstasis is significantly increased in pro-arthritic and arthritic conditions and that blocking the IL-17 and COX-2 pathways may significantly reduce the rate of metastasis."

Hopeful

07-31-2009, 06:55 AM	#1
Hopeful Senior Member Join Date: Aug 2006 Posts: 3,380	BC-associated metastasis is significantly increased in model of autoimmune arthritis Abstract:http://breast-cancer-research.com/co...4/R56/abstract Article (be patient, it takes a while to download because of the pictures):http://breast-cancer-research.com/co...df/bcr2345.pdf Please note this study was done in mice, not people. However, the conclusions are provocative: "Inflammation is a critical hallmark of arthritis and tumor progression. Many processes that occur during arthritis also occur during tumorigenesis. There is increased vascularity in both; and there are common cytokines and growth factors that are regulated in both. The microenvironment in the tumor and arthritis is largely orchestrated by inflammatory cells and growth factors. Thus, it is not unlikely that the two diseases commonly co-exist in women. . . . Our data provide clear evidence for the first time that breast cancer associated secondary metatstasis is significantly increased in pro-arthritic and arthritic conditions and that blocking the IL-17 and COX-2 pathways may significantly reduce the rate of metastasis." Hopeful Last edited by Hopeful; 07-31-2009 at 07:17 AM..