[Joe]

Marie,

Christine's radiation oncologist has told us that there is a theory on how many times a patient can receive Gamma Knife, but he has never seen it nor is aware of any case where a patient has ever reached the limit.

Clinical Trials: There are numerous clinical trials for HER2 bc. Fortunately you live near some major cancer centers and may qualify for some. Wyeth is planning to do a phase III trial of Neratinib, which is a small molecule and may go through the blood brain barrier. The phase II trial results were released at last December's San Antonio meeting and may soon be our next weapon.

We have been discussing, with Genentech, the possibility of releasing Herceptin T-DM1 for "compassionate" use and they seemed receptive to the idea. Keep your fingers crossed and your prayers coming that it happens as many lives will be saved. The FDA has already "fast tracked" the drug.

If you did see the movie about Dr. Slamon "Living Proof" the story of Barbara Bradfield is true, although she is nothing like Bernadette Peters. She was enrolled in the Phase I study of Herceptin, had a complete clinical cure, and is still alive and enjoying life - CANCER FREE

Here is a picture of Dr. Slamon, his wife and Barbara..she is in the middle.