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LOX actually is a gene that is secreted from the tumor, itself. In mammals, the predominant LOX substrate is arachidonic acid. Its products, the eicosanoids comprise a variety of bioregulators including leukotrienes, hepoxilins and HETEs, that play important roles in the maintenance of the homeostasis of the animal cell and also have been shown to be implicated in a variety of human diseases such as inflammation, fever, arthritis and cancer [11-15]. LOX are also able to oxidize complex lipids and modify membrane structures leading to structural changes that play a role in the maturation of various cell types including erythrocytes, lens epithelial cells, and keratinocytes [16].
This sounds so promising and many studies are being conducted as I write this, ie Stanford and others. I am praying this could be the magic bullet....
Love, Vickie
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Love and Hugs, Vickie
Life's not about waiting for the storm to pass,
It's about learning to dance in the rain.
Feb 04 IBC IIIC/IV er-/pr- her2+++
3/04 TCH X4
7/ 04 MRM 9/04 Taxol/herceptin wkly 1 yr 33X rads
11/04 skin mets 33x rads,10/05 Avast/Herc. 11 mos.
8/ 06 PET mets lymphs, neck
9/ 06 Navelbine/herceptin
11/ 06 PET NED
2/ 07 skin mets, 4/07 Xeloda, 5/07 add Tykerb
2/ 08 Tykerb failed. Doxil /Herceptin 6 months
8/08 PET skin mets, 8/08 Abraxane/Avastin
11/ 08 PET prog., skin mets
1/09 PET/CT progress, 1/09 Ixempra, 2/09 add Xeloda and low dose Naltrexone
2/09 off Ixempra/Xeloda
3/09 navelbine/herc/cytoxin 4/09 PET shows regress.7/09 start Topotecan. Failed.
8/09 extensive mets rgt brst, back and torso. starting Pazopanib clinical trial.
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