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Jean,
My recollection is that it takes about 18 weeks to fully "clear" the body of Herceptin after treatment ends. (My onc said to me, "Don't tell me I never gave you anything!")
Insofar as the lasting effects of the drug, no one really knows. I recall two papers that came out in 2007 that did a cost/benefit analysis of Herceptin from an insurance perspective (one was a Medscape article). I have them somewhere, but not ready to hand. In that paper, they used an assumption that Herceptin would provide 3 years of protection, and did comment that they thought it was an "outside" estimate. Of course, these folks are bean-counters and not scientists, but that is what I can recall seeing.
Hopeful
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