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I certainly have found it very difficult. Chemo brain affected my job performance in a very negative way. The employer responded to mistakes due to memory lapses with escalating disciplinary measures, and my co-workers would tease me about wanting "more time off". (I fully disclosed my chemo brain symptoms when I returned to work) I estimate that it has taken me about 4 years to regain "normal" memory retention levels.
For me, I figure that it was the long-term ongoing side effects of chemo that made it impossible to keep my old job.
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