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chrisy · 02-05-2009, 05:32 PM

Eric, I wish Caryn the best of success with this one. She sure deserves a break - and a treatment that works without being too difficult would be a good one.

There was a lot of talk at San Antonio on the epothilones (ixempra is the first one approved), so there's a lot of interest and enthusiasm on it. I hope it works well for Caryn.

Besides DM1, the most discussed her 2 targeting drug was the new one called neratinib. It had good efficacy even with people who had prior herceptin AND tykerb. However, the side effects were pretty severe diarreah in just about everyone. Seems people were able to deal with it eventually as there were no trial dropouts due to this, but it probably is not the best thing to mess with at this point if you have other good options.

Love and prayers,
Chris

02-05-2009, 05:32 PM	#9
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Eric, I wish Caryn the best of success with this one. She sure deserves a break - and a treatment that works without being too difficult would be a good one. There was a lot of talk at San Antonio on the epothilones (ixempra is the first one approved), so there's a lot of interest and enthusiasm on it. I hope it works well for Caryn. Besides DM1, the most discussed her 2 targeting drug was the new one called neratinib. It had good efficacy even with people who had prior herceptin AND tykerb. However, the side effects were pretty severe diarreah in just about everyone. Seems people were able to deal with it eventually as there were no trial dropouts due to this, but it probably is not the best thing to mess with at this point if you have other good options. Love and prayers, Chris __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure