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chrisy · 01-16-2009, 01:32 PM

Hi Barry,

The FDA approved indication for Avastin is, as you probably know, for first line. However many people have been able to get it - Sheila has been on Taxol/Avastin (her BCBS denied the Abraxane!) but I think that was just prior to the FDA approval. At any rate, it was "off label" when she got it.

I'm curious as to why no Her2 targeting agent is included in your proposed therapy?

This was a poster presented at San Antonio showing efficacy/safety of Avastin/Tykerb in Her2+ patients. I was on this study and did OK (stable for 8 months), but I know others here were on the same study until it closed and it was a very successful therapy.

More research is ongoing I'm sure, and there may be other data out there in other scenarios, but for your purposes this may serve as a small rebuttal to the "no study data available for Avastin in Her2+" excuse.

http://www.posters2view.com/sabcs08/viewp.php?nu=3133

Good luck, keep up the fight!

01-16-2009, 01:32 PM	#2
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Hi Barry, The FDA approved indication for Avastin is, as you probably know, for first line. However many people have been able to get it - Sheila has been on Taxol/Avastin (her BCBS denied the Abraxane!) but I think that was just prior to the FDA approval. At any rate, it was "off label" when she got it. I'm curious as to why no Her2 targeting agent is included in your proposed therapy? This was a poster presented at San Antonio showing efficacy/safety of Avastin/Tykerb in Her2+ patients. I was on this study and did OK (stable for 8 months), but I know others here were on the same study until it closed and it was a very successful therapy. More research is ongoing I'm sure, and there may be other data out there in other scenarios, but for your purposes this may serve as a small rebuttal to the "no study data available for Avastin in Her2+" excuse. http://www.posters2view.com/sabcs08/viewp.php?nu=3133 Good luck, keep up the fight! __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure