HER2 Support Group Forums - View Single Post - metformin (common anti diabetes drug) decreases her2 protein levels by 85%

jml · 01-10-2009, 06:32 PM

I've been taking Metformin for Insulin Resistance for the past 5 years. I'm not diabetic, just insulin resistant-presumably due to chronic exposure to chemotherapies/steroids, etc. I went to see an endocrinologist after my 1st year of treatment, was finally NED & finished w/chemo, but gained 18 lbs in ~4mos. We did a "glucose challenge" & that's how the IR was diagnosed.
Once on the Metformin, I shed the weight (YAY!) & now this news is a TOTAL BONUS!
I've recently explored the option of d/c'ing the Metformin w/my onc, but with this news, I think NOT!

01-10-2009, 06:32 PM	#10
jml Senior Member Join Date: Dec 2006 Posts: 415	I've been taking Metformin for Insulin Resistance for the past 5 years. I'm not diabetic, just insulin resistant-presumably due to chronic exposure to chemotherapies/steroids, etc. I went to see an endocrinologist after my 1st year of treatment, was finally NED & finished w/chemo, but gained 18 lbs in ~4mos. We did a "glucose challenge" & that's how the IR was diagnosed. Once on the Metformin, I shed the weight (YAY!) & now this news is a TOTAL BONUS! I've recently explored the option of d/c'ing the Metformin w/my onc, but with this news, I think NOT!