It's intra-
arterial delivery of chemo, supposedly preferred by MD Anderson.
http://www.mdanderson.org/department...od=displayfull
Regarding spheres, there does seem to be a double-talk amongst medical oncologists of the need to "reduce tumor burden" combined with the neglect of directed therapies that, at least intuitively, could help in that regard. I have, however, encountered interventional radiologists who seem to be open to combining the approaches. In other words, I don't get the impression that it has to be a local vs systemic equation.