HER2 Support Group Forums - View Single Post - T-DM1 starts tomorrow!

chrisy · 12-04-2008, 04:17 PM

Kim,

Glad to hear you got into the trial with no hiccups! I've been on a trial with the same dosing schedule since february. Like everything else it may not work for everyone but when it does, it's a really great therapy. I find it a bit tougher than plain Herceptin but well worth it and definitely better than chemo.

You may be interested to know, I went on the DM1 trial just after recurring on Tykerb/Avastin. I think of it as the Tykerb failing me, not the other way around...but it led me to the DM1 trial just as it was opening at UCSF. The point is, I was also a veteran of Herceptin and Tykerb and have had great response to the DM1.

If the protocols are anything like the trial I'm on, it could be very demanding in terms of follow up, scans, etc. If you have easy access to your trial location that won't be a problem.

Good luck on the trial!

12-04-2008, 04:17 PM	#8
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Kim, Glad to hear you got into the trial with no hiccups! I've been on a trial with the same dosing schedule since february. Like everything else it may not work for everyone but when it does, it's a really great therapy. I find it a bit tougher than plain Herceptin but well worth it and definitely better than chemo. You may be interested to know, I went on the DM1 trial just after recurring on Tykerb/Avastin. I think of it as the Tykerb failing me, not the other way around...but it led me to the DM1 trial just as it was opening at UCSF. The point is, I was also a veteran of Herceptin and Tykerb and have had great response to the DM1. If the protocols are anything like the trial I'm on, it could be very demanding in terms of follow up, scans, etc. If you have easy access to your trial location that won't be a problem. Good luck on the trial! __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure