HER2 Support Group Forums - View Single Post - Docetaxel didn't work-anyone had another taxaxe work?

chrisy · 11-12-2008, 02:43 PM

I had Taxol, not Taxotere. I always had Benadryl IV and a steroid premed, as did all the ladies who were getting infusions of Taxotere.

But, as Chelee said, things may have changed. I did just check on the attached link drug info link, and it clearly said premedication with a corticosteroid. It says oral in advance, but my doctor used IV just prior to infusion instead.

http://www.chemocare.com/bio/taxotere.asp

At any rate, the issue seems to be you reacted to taxotere (rather than it wasn't working), if you try Taxol (WITH appropriate premeds of steroid and benadryl) you may do fine. Or, you may be one of those people who are exquisitely sensitive to taxanes and it may not be an option. But I'd really push for getting the appropriate premeds before throwing in the towel on the taxanes.

Good luck

11-12-2008, 02:43 PM	#3
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	I had Taxol, not Taxotere. I always had Benadryl IV and a steroid premed, as did all the ladies who were getting infusions of Taxotere. But, as Chelee said, things may have changed. I did just check on the attached link drug info link, and it clearly said premedication with a corticosteroid. It says oral in advance, but my doctor used IV just prior to infusion instead. http://www.chemocare.com/bio/taxotere.asp At any rate, the issue seems to be you reacted to taxotere (rather than it wasn't working), if you try Taxol (WITH appropriate premeds of steroid and benadryl) you may do fine. Or, you may be one of those people who are exquisitely sensitive to taxanes and it may not be an option. But I'd really push for getting the appropriate premeds before throwing in the towel on the taxanes. Good luck __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure