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Jean · 11-07-2008, 09:19 PM

Dianne,
This test (topo2a) was recently approved in the US by our FDA...this test (it is still not standard practice yet)
determines if you are negative or positive for the
Topo2a which is a gene.

If you are topo2A positive than A/C chemo could be a choice...if you are topo2a negative you would have
resistance to A/C and it would serve little or no benefit.
This test has relevance to anthracycline treatments and can have dramatic effect on response to therapy.
There is new data suggesting a complex link between Her2 and TOPO2a genes in breast cancer.

I had the test and was negative - hence I had TCH
this treatment is becoming the standard especially for
early stage bc.

11-07-2008, 09:19 PM	#2
Jean Senior Member Join Date: Oct 2005 Location: New Jersey Posts: 3,154	Dianne, This test (topo2a) was recently approved in the US by our FDA...this test (it is still not standard practice yet) determines if you are negative or positive for the Topo2a which is a gene. If you are topo2A positive than A/C chemo could be a choice...if you are topo2a negative you would have resistance to A/C and it would serve little or no benefit. This test has relevance to anthracycline treatments and can have dramatic effect on response to therapy. There is new data suggesting a complex link between Her2 and TOPO2a genes in breast cancer. I had the test and was negative - hence I had TCH this treatment is becoming the standard especially for early stage bc. __________________ Stage 1, Grade 1, 3/30/05 Lumpectomy 4/15/05 - 6MM IDC Node Neg. (Sentinel node) ER+ 90% / PR-, Her2+++ by FISH Ki-67 40% Arimidex 5/05 Radiation 32 trt, 5/30/05 Oncotype DX test 4/17/06, 31% high risk TOPO 11 neg. 4/06 Stopped Arimidex 5/06 TCH 5/06, 6 treatments Herceptin 5/06 - for 1 yr. 9/06 Completed chemo Started Femara Sept. 2006 Last edited by Jean; 11-07-2008 at 09:45 PM..