[RobinP]

Harry Forteo is a long term acting injectable bisphophonate used for severe bone loss. I hope you folks that are using bisphosphonates are getting at least 800mg of vitamin D3 and 1500 mg of calcuim citrate per day. If you are not, you may be making bone density worse.

Bisphosphonates have long been thought to help prevent bone mets by decreasing bone turn-over. I took them for four years, but have since been on a drug holiday, as there are safety issues beyond four years of use concerning osteonecrosis of the jaw and concerns over the extreme long half life of the drug, where it is thought to terminally be in the bone and not broken down and lost.

Now I wonder if bisphosphonates really help prevent her2+ bc mets since it usually spread to the central nervous system as a first spread. Becky, any comments on this, that is how often does her2 bc spread to the bones?