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Pristiq is Desvenlafaxine, very similar to Venlafaxine (Effexor). It differs from Zoloft in that it inhibits the reuptake of both Serotonin and Norepinephrine. Zoloft only inhibits Serotonin reuptake. Common side effects of Pristiq include possible rises in blood pressure, nausea, drowsiness, constipation and others. The dosage is usually 50mg daily. As Pristiq effects two n neurotransmitter systems it may be more effective than the Zoloft which seems to be losing its efect. Other drugs that effect both the Serotonin and Norepinephrine system are Cymbalta and Effexor.
Paul
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