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Upregulation: increasing - downregulation: decreasing.
In this case, increasing the level of her2/neu.
Usually Increasing Her2/neu level indicates recurring disease or resisting disease. HOWEVER, the abstract specifically said that since the CA27.29 was "unchanged", this increasing in Her2/neu can not be used as a disease status indicator.
I don't think just this one study can be used to "...NOT taking drugs...estrogen..." as per Janelle question. Tripple postive (ER+, PR+, Her2+) tumor will "increase" the remaining receptors to compensate when the other is blocked. I think there are data that indicate Her2+ tumor become resistance to tamoxifen faster than Her2 negative.
Nguyen
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