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Old 09-02-2008, 08:35 PM   #7
Melissa
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Join Date: Jan 2008
Location: Virginia
Posts: 116
Hi,
You might ask your onc about the CYP2D6 tamoxifen test. It's a test to see if you have high or low CYP2D6 (if the liver can metabolize tamoxifen). Only 10% of people do not. I was among the 10% of poor metabolizers. This test is still controversial, some thinking maybe other factors contribute to metabolic rate of liver. You can read the research. If you don't metabolize tamoxifen some doctors say you won't experience symptoms such as hot flashes. SO hot flashes are good. I felt wonderful on tamoxifen, no hot flashes at all, so maybe I didn't metabolize it well. Who knows?? BUT if I could have taken tamoxifen I would have. It builds bones instead of tearing them down like the AI's. Women on tamoxifen also have the option, after 3-5 years on tamoxifen, of taking an AI another 3-5yrs. Wishing you the best!!
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Melissa

04/06, (42), 2cm tumor, 7/13 nodes, one positive node under clavicle
mastectomy/reconstruction
grade 3, stage lllb, er-65+, pr-90+, her2+++(80%)
4/AC, 12wks TH then 6wks rads
40 wks herceptin, and tamoxifen.
onc test tamoxifen resistance = poor metabilizer
04/07 ooph & on arimidex
08/07 completed herceptin

04/2022 - 16 year survivor!
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