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Jean is right. A pre-menopausal women should not take AIs without some form of ovarian suppression to make her in essence post menopausal. AIs reduce the amount of available estrogen by inhibiting the function of an enzyme that helps converse another substance (I can't remember what) into estrogen. If one is still pre-menopausal, this reduction actually could cause a negative feedback loop resulting in the production of more estrogen. I am on Femara, but I also have monthly Zoladex injections to suppress the function of my ovaries.
Jill
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