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I have had two surgeries while on Herceptin without any problem (mastectomy and exchange surgery). Indeed, my oncologist stressed that I must make sure to keep on schedule with the Herceptin, although I was having surgery. All the surgeons were aware of the Herceptin treatment and did not view this as an issue. I would have your oncologist talk with your surgeon about this. You also might want to have the surgeon think about other possible causes for the drop in temperature, since I assume you would want to avoid this problem in the future.