HER2 Support Group Forums - View Single Post - One Size Fits All Aromatase Inhibitor????

CLTann · 06-11-2008, 04:11 PM

Hi,

I was having bone density loss, although I have been, off and on, taking Fosamaz weekly. I asked my onc today why do I ( small frame and lean) need to take the same dosage of Femera as a big woman does. He said it is the enzyme in the body that the A.I. trying to counteract. Since no one can gauge the amount of enzyme, the dosage has been set at a standard amount for everyone. There is no data to support the efficacy at a lower dosage or less frequency. As to the bone loss, he asked me to do the best in getting tolerance with biphosphate. Another bone density specialist is recommended.

06-11-2008, 04:11 PM	#12
CLTann Senior Member Join Date: Oct 2005 Posts: 476	Hi, I was having bone density loss, although I have been, off and on, taking Fosamaz weekly. I asked my onc today why do I ( small frame and lean) need to take the same dosage of Femera as a big woman does. He said it is the enzyme in the body that the A.I. trying to counteract. Since no one can gauge the amount of enzyme, the dosage has been set at a standard amount for everyone. There is no data to support the efficacy at a lower dosage or less frequency. As to the bone loss, he asked me to do the best in getting tolerance with biphosphate. Another bone density specialist is recommended. __________________ Ann Stage 1 dx Sept 05 ER/PR positive HER2 +++ Grade 3 Invasive carcinoma 1 cm, no node involvement Mastec Sept 05 Annual scans all negative, Oct 06 Postmenopause. Arimidex only since Sept 06, bone or muscle ache after 3 month Off Arimidex, change to Femara 1/12-07, ache stopped Sept 07 all tests negative, pass 2 year mark Feb 08 continue doing well. Sep 09 four year NED still on Femara.