HER2 Support Group Forums - View Single Post - brain mets update -- follow-up

Lani · 06-08-2008, 02:13 PM

intrathecal herceptin (ie given into the cerebrospinal fluid)

I have also posted information before on Boswellia serrata

here is an abstract with an email address
Journal of Neuro-Oncology
2006
10.1007/s11060-006-9248-4
Clinical–Patient Studies

A lipoxygenase inhibitor in breast cancer brain metastases
D. F. Flavin1

(1) Foundation for Collaborative Medicine and Research, 24 Midwood Drive, Greenwich, CT 06831, USA

D. F. Flavin
Email: Dana_FK@hotmail.com
Received: 23 July 2006 Accepted: 11 August 2006 Published online: 26 September 2006

Abstract The complication of multiple brain metastases in breast cancer patients is a life threatening condition with limited success following standard therapies. The arachidonate lipoxygenase pathway appears to play a role in brain tumor growth as well as inhibition of apoptosis in in-vitro studies. The down regulation of these arachidonate lipoxygenase growth stimulating products therefore appeared to be a worthwile consideration for testing in brain metastases not responding to standard therapy. Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition. Multiple brain metastases were successfully reversed using this method in a breast cancer patient who had not shown improvement after standard therapy. The results suggest a potential new area of therapy for breast cancer patients with brain metastases that may be useful as an adjuvant to our standard therapy.
Keywords Cancer - Lipoxygenase - Boswellia serrata - Oxidoreductase inhibitor - LOX inhibitors - Lipoxygenase inhibitor - Brain Cancer - Breast Cancer - Metastases - Breast Cancer Remission - Arachidonate: Oxygen oxidoreductase - Herceptin

Hope some of this helps!

06-08-2008, 02:13 PM	#12
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	there was a poster at ASCO on something I have posted about before intrathecal herceptin (ie given into the cerebrospinal fluid) I have also posted information before on Boswellia serrata here is an abstract with an email address Journal of Neuro-Oncology 2006 10.1007/s11060-006-9248-4 Clinical–Patient Studies A lipoxygenase inhibitor in breast cancer brain metastases D. F. Flavin1 (1) Foundation for Collaborative Medicine and Research, 24 Midwood Drive, Greenwich, CT 06831, USA D. F. Flavin Email: Dana_FK@hotmail.com Received: 23 July 2006 Accepted: 11 August 2006 Published online: 26 September 2006 Abstract The complication of multiple brain metastases in breast cancer patients is a life threatening condition with limited success following standard therapies. The arachidonate lipoxygenase pathway appears to play a role in brain tumor growth as well as inhibition of apoptosis in in-vitro studies. The down regulation of these arachidonate lipoxygenase growth stimulating products therefore appeared to be a worthwile consideration for testing in brain metastases not responding to standard therapy. Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition. Multiple brain metastases were successfully reversed using this method in a breast cancer patient who had not shown improvement after standard therapy. The results suggest a potential new area of therapy for breast cancer patients with brain metastases that may be useful as an adjuvant to our standard therapy. Keywords Cancer - Lipoxygenase - Boswellia serrata - Oxidoreductase inhibitor - LOX inhibitors - Lipoxygenase inhibitor - Brain Cancer - Breast Cancer - Metastases - Breast Cancer Remission - Arachidonate: Oxygen oxidoreductase - Herceptin Hope some of this helps!