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Hi AA,
I'm not Brenda but your questions interest me. I don't think the answers are known about hormonal treatment and response, if I understand your question correctly. Are you saying that benefit from hormonal therapy might be stronger not just related to degree of estrogen receptor positivity of the tumor cells but also r/t baseline levels of endogenous estrogen according to menopausal status? As much as they've looked at benefit of Tamoxifen in all age groups, it would seem that they would have noticed if there were a significant variation. At least between the two extremes of definitely post or pre menopausal. I don't think they saw that. Tamoxifen's benefit is not usually stratified according to menopausal status, is it?
Regarding whether those who have more menopausal symptoms rather than less, regarding Tamoxifen, they do think (now) that this may be making a difference, because they are thinking that those who have few symptoms are likely to be the ones who have less of the enzyme required to metabolize Tamoxifen. If you google Tamoxifen cypd6, you'll find enough to get you started looking at that issue. My issue with this line of thought is that they are not explaining how this relates to the fact that many woman pass thru natural menopause without symptoms while other suffer extreme symptoms - and there is no Tamoxifen metabolism in the picture - so there must be other differences to be taken into account. I don't think the same enzymes/issues are involved in AI metabolism but there could be similar issues - who knows?
And lastly, I admit to not fully understanding what you mean by "loss of gender". I do feel that I had/have a fair number of side effects from my two years of Arimidex but if by "loss of gender" you mean not feeling feminine - that has not been a problem for me. I thought that if anything, my flat chest would lessen my sense of feminity but again, I still feel the same in that regard. In fact if anything (reading and writing about this thread is taking me deeper into it), I think I would say that lacking several of the qualities that would be considered most feminine (breasts and a smoothly-functioning vagina) has strengthened my sense of myself as feminine. Who I am, gender-wise, doesn't come from my parts - it comes from some place of mystery and I'm content to leave that to mystery.
Serendipitously, I'm listening to an interesting book on CD. This is a little graphic so stop now if you'd rather not hear about gender issues. I cannot remember why I put this book on my rental list but I don't think I realized what it was about. When I first began listening I was shocked at the graphic descriptions and language but there's a core of deep heartfelt emotions and love plus some great humor and insight, and I'm still listening, now more than halfway thru. It's a novel written in the first person and the person is a gay man. The author, I assume, is also gay - he talks with the voice of experience it seems to me.
Nevermind - I started to type more details and decided it might be offensive to some. Bottom line made in this entertaining and sweet novel is that how we relate to each other and how we enjoy our sexual selves is almost entirely in our minds (and I would add, in our hearts). It's not in our "equipment". Our equipment simply provides the tools for us to use. But that kernel of "us-ness" that tells us our gender - that it a mystery. Where does it come from? It's not hormones, at least not as we know them. For example, women given testosterone do not begin to see themselves as men (yes, they may have some symptoms that are manlike, but that's not the same as one's perception of one's gender). Many people who identify themselves as transgender will say that they knew from an early age (before traditional male/female hormones were even active) that they were not right in their bodies.
No answers from me. Just more questions and ramblings. There's a lot that we do not understand, and maybe that's an okay thing. Except of course as it relates to treatment of breast cancer and there we want to understand everything, eventually (or better yet, tomorrow).
Debbie Laxague
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