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Interleukin 8 is one of many cyokines. apparently it is necessary or involved in the metastasis of breast cancer cells. apparently this Dasch gene protein inhibits metastasis by inhibiting the action of interleukin 8 when it is functioning properly.
It would be quite possible to develop a monoclonal antibody to inhibit interleukin 8 and help slow down metastasis. Avastin is a monoclonal antibody that inhibits Vascular Endothelial Growth Factor. Herceptin is a monoclonal antibody that in hibits the Her2Neu protein. Tocilizumab is a monoclonal antibody being developed against Interleukin 6 and is to be used to treat severe Rheumatoid Arthritis.Interleukin 6 is very involved in the cancer known as Multiple Myeloma so theoretically Tocilizumab might be valable in this disease too.
This new info about Dasch and Interlekin 8 opens p a new area to target. NF Kappa beta is also mentioned. Stimulation of NFKappa beta causes Interleukin 6 release and apparently the Dasch gene also inhibits this target also. In fact when NFKappa b is activated a large number of "pro-cancer" (for lack of a better word) chemicals are activated. I know as a pharmacist that NSAID drgs like Aspirin and Celebrex inhibit NFKappa b also and could be used in combination with this antibody against Interleukin 8, when it is developed.
Paul
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