[Becky]

Dear Julie

I suppose a question to ask about the trial is when does it close and how many past chemos are you allowed to have before you can't get into it (sometimes trials exclude heavily pretreated women). That way you might know that the trial is a now or never kind of thing.

Another question to ask is if the Herceptin/Tykerb combo can be combined with a chemo (I am thinking Navelbine since it worked in the past) as the targeted therapies tend to work better if combined with something else.

Is you cancer hormone positive? If it wasn't, maybe its time to biopsy to see if it has changed to hormone positive. Then other drugs can also be employed. This DOES happen and it is ONLY a thought.

Those nodes seem to be pesky but it seems it doesn't wreck havoc anywhere else.

I do know that Lolly also used radiation but she will have to comment if that worked or not.

I think if you get clearer imput from your onc, the right thing to do will come to you naturally. You have tons of options left to kick cancer out the door. I will be thinking about you and if I think of any other questions, I will post again.