HER2 Support Group Forums - View Single Post - Anybody on Herceptin+Tykerb without chemo?

Barbara H. · 03-29-2008, 10:54 AM

Hi Julie,
This is the report that I received July 9, 1998:
Invasive ductal carcinoma, at least 2.0 cm (tumor present in fibrous tissue over a 7 cm diameter area, moderately-differentiated. E/R and PR negative. The deep margin is free of both invasive and in-situ carcinoma. Extensive lymphovascular invasion is present, including dermal lymphatics. DCIS is present, including solid, comedo and micropapillary subtypes. In-situ carcinoma is seen in association with invasive tumor, and comprises approximately 20% of the invasive tumor. Metastatic adenocarcinoma involving seven of nine lymph nodes with extrandodal extension. At the time there was no mention on the report of HER 2 positve. A few years later my oncologist informed me that I has HER 2 positive, but I never saw that additional pathology report. It is interesting to note that it took me six years with ER and PR neg to recur. That seems to be unusual with my profile. It is also significant that I responded so well at first to Herceptin. I wish it had continued working by itself. Thankfully, it did not allow it to return to the places of the original mets. My CT scans are currently only showing stable disease. Does anyone know how you can determine if you are NED in the bones. All my tumor markers are now currently normal.
Thanks,
Barbara H.

03-29-2008, 10:54 AM	#7
Barbara H. Senior Member Join Date: Sep 2005 Location: Newton, MA Posts: 951	Pathology Hi Julie, This is the report that I received July 9, 1998: Invasive ductal carcinoma, at least 2.0 cm (tumor present in fibrous tissue over a 7 cm diameter area, moderately-differentiated. E/R and PR negative. The deep margin is free of both invasive and in-situ carcinoma. Extensive lymphovascular invasion is present, including dermal lymphatics. DCIS is present, including solid, comedo and micropapillary subtypes. In-situ carcinoma is seen in association with invasive tumor, and comprises approximately 20% of the invasive tumor. Metastatic adenocarcinoma involving seven of nine lymph nodes with extrandodal extension. At the time there was no mention on the report of HER 2 positve. A few years later my oncologist informed me that I has HER 2 positive, but I never saw that additional pathology report. It is interesting to note that it took me six years with ER and PR neg to recur. That seems to be unusual with my profile. It is also significant that I responded so well at first to Herceptin. I wish it had continued working by itself. Thankfully, it did not allow it to return to the places of the original mets. My CT scans are currently only showing stable disease. Does anyone know how you can determine if you are NED in the bones. All my tumor markers are now currently normal. Thanks, Barbara H.