HER2 Support Group Forums - View Single Post - AI induced bone and joint pain more common that reflected in clinical trials

TSund · 03-07-2008, 10:08 AM

Thanks Lani! Yes, I've looked at the video, and looked at some of the studies as well. When we spoke with our oncologist she ran the blood test that checked for this factor. As I understand it, a significant % of women (I was remembering about 5%, the article below says 7 -10%!) are poor metabolizers of tamoxifen, due to a certain gene/enzyme combination.

http://talk.dnadirect.com/2006/10/14...fen-2d6-genes/

If the drug company studies are not testing the women for this factor or taking into account the % of women that are poor metabolizers, then it seems to me that the statistics comparing the two are flawed. Don't get me wrong, I am not promoting one drug over the other and I have discomfort with both, but am just trying to get this straight. Has this factor been discussed elsewhere here on the board (or off!)

03-07-2008, 10:08 AM	#12
TSund Senior Member Join Date: May 2007 Location: DFW area (TX) Posts: 431	Thanks Lani! Yes, I've looked at the video, and looked at some of the studies as well. When we spoke with our oncologist she ran the blood test that checked for this factor. As I understand it, a significant % of women (I was remembering about 5%, the article below says 7 -10%!) are poor metabolizers of tamoxifen, due to a certain gene/enzyme combination. http://talk.dnadirect.com/2006/10/14...fen-2d6-genes/ If the drug company studies are not testing the women for this factor or taking into account the % of women that are poor metabolizers, then it seems to me that the statistics comparing the two are flawed. Don't get me wrong, I am not promoting one drug over the other and I have discomfort with both, but am just trying to get this straight. Has this factor been discussed elsewhere here on the board (or off!) __________________ Terri, spouse of Ruth, Dallas/Ft. Worth area Ruth dx 05/01/07 (age 50) Filipino multifocal, several tumors .5 -2.5 cm, large area Breast MRI showed 2 enlarged nodes, not palpable 100%ER+, 95%PR+, HER2+++ 6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage 1 year Herceptin till 6/08 MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells" now 50% ER+, PR- ??? Rads finished 1/16/08 Added Tamoxifen, Finished Herceptin 05/08 NOW is the time to appreciate life to the fullest.