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I don't know that they have really tested enough
people (or that the testing method is accurate enough when done in most labs)
to really know how many have a different/better/worse metabolism of tamoxifen
Supposedly if tamoxifen takers get hot flashes that is a good sign that it is working(paper given at 2006 SAN ANTONIO MEETING I BELIEVE),but if one doesn't get hot flashes that doesn't necessarily mean it isn't working
Everyone's favorite mouse "triple cure" experiment by the Osborne/Schiff/Arpino team used estrogen deprivation as I recall rather than tamoxifen--I recommend you watch Dr. Osbornes talk videos from the Miami bc conference that I posted the link to a couple of weeks ago to check out his reasoning regarding different antihormonals for her2+s
Dr. Slamon has stated at meetings that he thinks faslodex may be best for her2s, but it doesn't seem to be available for those who haven't failed on either tamoxifen or AIs
If you use the search function you may find lots of abstracts, links I have posted on the relative merits of different antihormonals in her2+ breast cancer
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