HER2 Support Group Forums - View Single Post - AI induced bone and joint pain more common that reflected in clinical trials

Lani · 03-06-2008, 09:37 PM

estrogen depletion in and of itself causes tendons and ligaments to tighten and become more elastic (why few 80 years can do the splits!)

Estrogen serves as a steroidal antiinflammatory in joints

Originally they thought that vitamin D levels which were low in bc patients might have something to do with it, but I don't think that has panned out, although it is still being looked into

Supplementing vitamin D didn't have the beneficial effect on this they had hoped for I was told by one researcher at a conference

I read today that statins can cause tendon deterioration and rupture, so perhaps RB can chime in with his views/information on the value of omega3s and 6s on this issue as it is possible that fat metabolism is involved

Hope this helped

03-06-2008, 09:37 PM	#7
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	theories--not reallydeveloped yet--just musings: estrogen depletion in and of itself causes tendons and ligaments to tighten and become more elastic (why few 80 years can do the splits!) Estrogen serves as a steroidal antiinflammatory in joints Originally they thought that vitamin D levels which were low in bc patients might have something to do with it, but I don't think that has panned out, although it is still being looked into Supplementing vitamin D didn't have the beneficial effect on this they had hoped for I was told by one researcher at a conference I read today that statins can cause tendon deterioration and rupture, so perhaps RB can chime in with his views/information on the value of omega3s and 6s on this issue as it is possible that fat metabolism is involved Hope this helped