HER2 Support Group Forums - View Single Post - Olive oil and Her2 downregulation

chrisy · 02-12-2008, 12:25 PM

Robin,
As you can tell, I'm not a science person either, but I interpreted the second article as it decreased the cleavage (that is to say, the discarding of the extracellular "docking station") so to me that would present more receptors.

Really need some help from people who understand this stuff! I didn't get to see the doctor yesterday but will start there with these studies.

I think EVOO (as well as other nutritional interventions) are not prescribed is that the data is not compelling enough - there is evidence, but not "proof" that this effect is seen in humans. All these studies were in the petri dish I think. But I think human studies may be underway which is good, we definitely need answers. Joe posted I think in "articles of interest" a link to MD Anderson's complementary website evaluating this stuff. It was really good, but in terms of grades, most things were not conclusive and got a "C".

02-12-2008, 12:25 PM	#13
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Robin, As you can tell, I'm not a science person either, but I interpreted the second article as it decreased the cleavage (that is to say, the discarding of the extracellular "docking station") so to me that would present more receptors. Really need some help from people who understand this stuff! I didn't get to see the doctor yesterday but will start there with these studies. I think EVOO (as well as other nutritional interventions) are not prescribed is that the data is not compelling enough - there is evidence, but not "proof" that this effect is seen in humans. All these studies were in the petri dish I think. But I think human studies may be underway which is good, we definitely need answers. Joe posted I think in "articles of interest" a link to MD Anderson's complementary website evaluating this stuff. It was really good, but in terms of grades, most things were not conclusive and got a "C". __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure