[Jean]

Hi Rebecca,
Yes, I was tested for TOPO 11.
When I was at the SABCS Dr. Slamon spoke again about the TOPO 11 test and the benefit of the test would be for those patients that have not had
treatment yet. If you are TOPO 11 positive than A/C chemo would be
the better treatment, if TOPO 11 negative then A/C chemo would not
chosen. Women who are TOPO 11 positive and Her2 would have a greater benefit from the A/C.

I was TOPO 11 negative and was tested by Dr. Slamon 2006 he advised
TCH which I did. He also advised that the TCH trials showed a small
difference between the A/C and TCH treatment I think it was a 3% difference and the TCH treatments did not increase heart risk to the patient.

I am glad this has been FINALLY approved by the FDA since in S.A.
one top Onc. was stating to Dr. Slamon on the panel one night that this test was not approved by our FDA (she was from France). Glad
that NOW woman will be able to test further what chemo will be their
best choice with less risk.

I was very surprised that many onc. do not even know about the test.
If you have any other questions just reach out.

Kind Regards,
Jean