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R.B. · 02-03-2008, 02:09 PM

There are several trials suggesting COX2 omega 6 products including PGE2 are a factor in BC. It is also reported to be a factor in melanoma.

Reducing omega six intake and increasing long chain omega three (EPA and DHA) is reported to assist in reducing PGE2 [Omega 3 fatty acids in clinical nutrition - Heller and Koch]

http://her2support.org/vbulletin/sho...&highlight=cox

http://cancerres.aacrjournals.org/cg...tract/61/1/303

Expression of Cyclooxygenase 2 in Human Malignant Melanoma
Carsten Denkert, Martin Köbel, Stefan Berger, Antje Siegert, Anja Leclere, Uwe Trefzer and Steffen Hauptmann1

Institute of Pathology [C. D., M. K., S. B., A. S., A. L., S. H.] and Department of Dermatology and Allergy [U. T.], Charité Hospital, D-10117 Berlin, Germany

"All melanoma cell lines produced prostaglandin (PG) E2 between 468 and 3500 pg/ml as determined by ELISA. Treatment with NS-398 (50 µM), a specific inhibitor of COX-2, suppressed PGE2 production of all melanoma cell lines by 50–96%. The IC50 for inhibition of PGE2 production by NS-398 was determined as 4 µM, indicating that NS-398 acts via inhibition of the COX-2 isoenzyme. We could show that proliferation of melanoma cell lines was not influenced by treatment with NS-398 in concentrations up to 100 µM. However, NS-398 reduced Matrigel invasion of all five malignant melanoma cell lines by 50–68%. Our results indicate that COX-2 is expressed in malignant melanomas and may be involved in regulation of melanoma invasion. It remains to be investigated whether selective inhibitors of COX-2 might be useful for prevention or treatment of malignant melanoma."

02-03-2008, 02:09 PM	#19
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	There are several trials suggesting COX2 omega 6 products including PGE2 are a factor in BC. It is also reported to be a factor in melanoma. Reducing omega six intake and increasing long chain omega three (EPA and DHA) is reported to assist in reducing PGE2 [Omega 3 fatty acids in clinical nutrition - Heller and Koch] http://her2support.org/vbulletin/sho...&highlight=cox http://cancerres.aacrjournals.org/cg...tract/61/1/303 Expression of Cyclooxygenase 2 in Human Malignant Melanoma Carsten Denkert, Martin Köbel, Stefan Berger, Antje Siegert, Anja Leclere, Uwe Trefzer and Steffen Hauptmann1 Institute of Pathology [C. D., M. K., S. B., A. S., A. L., S. H.] and Department of Dermatology and Allergy [U. T.], Charité Hospital, D-10117 Berlin, Germany "All melanoma cell lines produced prostaglandin (PG) E2 between 468 and 3500 pg/ml as determined by ELISA. Treatment with NS-398 (50 µM), a specific inhibitor of COX-2, suppressed PGE2 production of all melanoma cell lines by 50–96%. The IC50 for inhibition of PGE2 production by NS-398 was determined as 4 µM, indicating that NS-398 acts via inhibition of the COX-2 isoenzyme. We could show that proliferation of melanoma cell lines was not influenced by treatment with NS-398 in concentrations up to 100 µM. However, NS-398 reduced Matrigel invasion of all five malignant melanoma cell lines by 50–68%. Our results indicate that COX-2 is expressed in malignant melanomas and may be involved in regulation of melanoma invasion. It remains to be investigated whether selective inhibitors of COX-2 might be useful for prevention or treatment of malignant melanoma."